LATS1/2 Polyclonal Antibody

Catalog Number : A340583
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Introduction

The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments. LATS2 encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis.

General Information

Reactivity	Mouse
Application	WB, IHC, ELISA
Clonality	Polyclonal
Conjugate	Non-conjugated
Uniprot	O95835,Q9NRM7
Isotype	IgG
Immunogen	Synthesized peptide derived from human LATS1/2 around the non-phosphorylation site of Thr1079/1041.
Storage buffer	PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.3
Storage instruction	Store at -20℃. Avoid freeze / thaw cycles.
Alias	LATS1,WARTS,Serine/threonine-protein kinase LATS1,Large tumor suppressor homolog 1,WARTS protein kinase,h-warts,LATS2,KPM,Serine/threonine-protein kinase LATS2,Kinase phosphorylated during mitosis protein,Large tumor suppressor ho