General Information
Application | Inhibitor |
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Description | Regorafenib (BAY 73-4506) is a multi-target inhibitor for VEGFR1, VEGFR2, VEGFR3, PDGFRβ, Kit, RET and Raf-1 with IC50 of 13 nM/4.2 nM/46 nM, 22 nM, 7 nM, 1.5 nM and 2.5 nM in cell-free assays, respectively. |
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Cas NO. |
755037-03-7 |
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Purity | ≥99% |
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Molecular Weight | 482.82 |
Formula | C21H15ClF4N4O6 |
Target / IC50 |
RET : 1.5nM Raf-1 : 2.5nM VEGFR2 : 4.2nM Kit : 7nM VEGFR1 : 13nM |
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Solubility |
DMSO: 97 mg/mL Water: insoluble Ethanol: Insoluble |
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Storage |
Powder : -20°C for 3 years |
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|
1 mg |
5 mg |
10 mg |
|
1 mM |
1.0436 mL | 5.2180 mL | 10.4360 mL | |
5 mM | 0.2087 mL | 1.0436 mL | 2.0872 mL | |
10 mM | 0.1044 mL | 0.5218 mL | 1.0436 mL |