General Information
| Application | Inhibitor |
|---|
| Description | Regorafenib (BAY 73-4506) is a multi-target inhibitor for VEGFR1, VEGFR2, VEGFR3, PDGFRβ, Kit, RET and Raf-1 with IC50 of 13 nM/4.2 nM/46 nM, 22 nM, 7 nM, 1.5 nM and 2.5 nM in cell-free assays, respectively. |
|---|
| Cas NO. |
755037-03-7 |
|---|
| Purity | ≥99% |
|---|---|
| Molecular Weight | 482.82 |
| Formula | C21H15ClF4N4O6 |
| Target / IC50 |
RET : 1.5nM Raf-1 : 2.5nM VEGFR2 : 4.2nM Kit : 7nM VEGFR1 : 13nM |
|---|
| Solubility |
DMSO: 97 mg/mL Water: insoluble Ethanol: Insoluble |
|---|
| Storage |
Powder : -20°C for 3 years |
|---|
|
|
1 mg |
5 mg |
10 mg |
|
|
1 mM |
1.0436 mL | 5.2180 mL | 10.4360 mL | |
| 5 mM | 0.2087 mL | 1.0436 mL | 2.0872 mL | |
| 10 mM | 0.1044 mL | 0.5218 mL | 1.0436 mL | |
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