Smad1/5/9 Polyclonal Antibody

Catalog Number : A22916PI
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Introduction

SMAD family member 1(SMAD1) Homo sapiens The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-med

General Information

Reactivity	Human, Mouse, Rabbit
Application	WB, IF, IHC, ELISA
Host	Rabbit
Uniprot	Q15797/Q99717/O15198
Immunogen	The antiserum was produced against synthesized peptide derived from human Smad1/5/9. AA range:10-59
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Formula	Liquid in PBS containing ₅₀% glycerol, ₀.₅% BSA and ₀.₀₂% sodium azide.
Alias	SMAD1; BSP1; MADH1; MADR1; Mothers against decapentaplegic homolog 1; MAD homolog 1; Mothers against DPP homolog 1; JV4-1; Mad-related protein 1; SMAD family member 1; SMAD 1; Smad1; hSMAD1; Transforming growth factor-beta-signaling protein

Subcellular Location：

intracellular,nucleus,nuclear inner membrane,nucleoplasm,transcription factor complex,cytoplasm,cytosol,integral component of membrane,protein complex,SMAD protein complex,

Expression：

Kidney,Mammary carcinoma,Placenta,Uterus,

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