COVID-19 
, COVID-19 Related Compounds
Tamoxifen Citrate
- Catalog Number : C5137
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Introduction
Tamoxifen(ICI-46474) is an antagonist of the estrogen receptor in breast tissue via its active metabolite, hydroxytamoxifen.in vitro: 4-hydroxytamoxifen, the active metabolite of tamoxifen, estradiol and 13 estradiol metabolites were tested in concentrations ranging from 3.1 to 100 microM. Incubation time was 4 days and cell proliferation was measured by means of the ATP chemosensitivity test. 4-hydroxytamoxifen showed an IC50 value of 27 microM and 18 microM in MCF-7 and MDA-MB 231 cells, respectively. Tamoxifen failed to significantly inhibit T-47Daro spheroid cell proliferation over a 100-500 nM concentration range. in vivo: 30 μg tamoxifen/g body weight/day injected on three consecutive days is the optimal condition for the αMHC-MerCreMer system to induce recombination in the Rosa26-lacZ strain. MAPK signaling can be transiently activated in the brain, liver, or kidney of Braf(V637E)ER(T2) mice by a single injection of tamoxifen. Braf(V637E)ER(T2) mice provide a new versatile tool to study disease mechanisms elicited by MAPK activation, complementing gene knockout technology that is restricted to the analysis of loss-of-function phenotypes.
General Information
| Cas No. | 54965-24-1 |
|---|---|
| Purity | >98% |
| Molecular Weight | 563.64 |
| Formula | C32H37NO8 |
| Solubility | DMSO : 250 mg/mL/ H2O：< 0.1 mg/mL |
| Storage instruction | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
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