COVID-19 
, COVID-19 Related Compounds
PX 12
- Catalog Number : C5130
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Introduction
PX-12(IV-2) is an irreversible inhibitor of Thioredoxin-1(Trx-1) currently in clinical development as an antitumor agent; IC50=7 uM in Hela, MTT assay, 72 h.Based on MTT assays, PX-12 inhibited the growth of HeLa cells with an IC50 value of ~7 μM at 72 h. DNA flow cytometry analysis indicated that 5 and 10 μM PX-12 significantly induced a G2/M phase arrest of the cell cycle. PX-12 also increased the number of dead cells and annexin V-fluorescein isothiocyanate-positive cells For the detailed information of PX 12, the solubility of PX 12 in water, the solubility of PX 12 in DMSO, the solubility of PX 12 in PBS buffer, the animal experiment (test) of PX 12, the cell expriment (test) of PX 12, the in vivo, in vitro and clinical trial test of PX 12, the EC50, IC50,and affinity,of PX 12, Please contact DC Chemicals.
General Information
| Cas No. | 141400-58-0 |
|---|---|
| Purity | >98% |
| Molecular Weight | 188.31 |
| Formula | C7H12N2S2 |
| Solubility | DMSO : ≥ 44.7 mg/mL/ H2O：ethanol：50 mg/mL |
| Storage instruction | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
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