Introduction
RXDX-106 (CEP-40783) is an orally-available, potent and selective TAM(TYRO3, AXL, MER)/MET inhibitor displaying low nanomolar biochemical activity and slow (T1/2 >120 min) inhibitor off-rate in peptide phosphorylation assays and in vitro kinase binding assays, respectively.
General Information
| Cas No. | 1437321-24-8 |
|---|---|
| Purity | ≥ 99% |
| Molecular Weight | 588.56 |
| Formula | C31H26F2N4O6 |
| Solubility | DMSO 10 mg/mL (16.99 mM) | Ethanol 2 mg/mL (3.40 mM) | Water Insoluble |
| Storage instruction | -20°C powder | -80°C in solvent |
|
Target |
Value |
Cell Line |
|
Axl |
IC50:7 nM |
Cell-free assay |
|
c-Met |
IC50:12 nM |
Cell-free assay |
|
Tyro3 |
IC50:19 nM |
Cell-free assay |
|
MER |
IC50:29 nM |
Cell-free assay |
|
Tyro3 |
IC50:29 nM |
Cell-free assay |
|
VEGFR2 |
IC50:960 nM |
Cell-free assay |
Chemical Structure
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