Antibody, Antibody Sampler Kit
Translational Control Antibody Sampler Kit
- Catalog Number : AK0275
- Number : AK0275
-
Size:
Qty : - Price : Request 詢價
- Stock : Request
-
Introduction
A variety of factors contribute to the important biological event of translation initiation. The Eukaryotic initiation Factor 4E (eIF4E) complex of translation initiation factors binds to the 5' m7 GTP cap to open up the mRNA secondary structure and allow small ribosome subunit binding. eIF4A, an eIF4 complex component that acts as an ATP-dependent RNA helicase, unwinds the secondary structure of the 5' mRNA untranslated region to mediate ribosome binding. EIF4E binds to the mRNA cap structure to mediate the initiation of translation. eIF4E interacts with eIF4G, a scaffold protein that promotes assembly of eIF4E and eIF4A into the eIF4F complex. eIF4B is thought to assist the eIF4F complex in translation initiation. eIF4H induces the RNA-dependent ATP hydrolysis catalyzed by the initiation factors eIF4A and eIF4B. eIF4H was further shown to determine the initial rate and extent of eIF4A-mediated mRNA secondary structure unwinding.
General Information
| Application | WB |
|---|---|
| Storage instruction | Store at -20℃. Avoid freeze / thaw cycles. |
| Research topic | Translational regulation |
.png)