Antibody, Antibody Sampler Kit
Translation Initiation Complex Antibody Sampler Kit
- Catalog Number : AK0274
- Number : AK0274
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Introduction
A variety of factors contribute to the important biological event of translation initiation. The Eukaryotic initiation Factor 4E (eIF4E) complex of translation initiation factors binds to the 5' m7 GTP cap to open up the mRNA secondary structure and allow small ribosome subunit binding. eIF4A, an eIF4 complex component that acts as an ATP-dependent RNA helicase, unwinds the secondary structure of the 5' mRNA untranslated region to mediate ribosome binding. EIF4E binds to the mRNA cap structure to mediate the initiation of translation. eIF4E interacts with eIF4G, a scaffold protein that promotes assembly of eIF4E and eIF4A into the eIF4F complex. eIF4B is thought to assist the eIF4F complex in translation initiation. eIF4H induces the RNA-dependent ATP hydrolysis catalyzed by the initiation factors eIF4A and eIF4B. eIF4H was further shown to determine the initial rate and extent of eIF4A-mediated mRNA secondary structure unwinding.
General Information
| Reactivity | Human |
|---|---|
| Application | WB, ELISA |
| Host | Rabbit |
| Clonality | Polyclonal |
| Conjugate | HRP,Non-conjugated |
| Storage instruction | Store at -20℃. Avoid freeze / thaw cycles. |
| Research topic | Translational regulation |
Product Includes
| Product name | Quantity | Applications | Reactivity | Host |
| EIF4E Polyclonal Antibody | 20μL | WB,IHC,ELISA | Human, Mouse, Rat, Monkey | Rabbit |
| Phospho-EIF4E (Ser209) Polyclonal Antibody | 20μL | WB,IHC,ELISA | Human, Mouse, Rat | Rabbit |
| EIF4G1 Polyclonal Antibody | 20μL | WB,IHC,ELISA | Human | Rabbit |
| Goat Anti-Rabbit IgG (H+L)(peroxidase/HRP conjugated) | 120μL | WB,ELISA |
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