Antibody, Antibody Sampler Kit
Src Antibody Sampler Kit
- Catalog Number : AK0266
- Number : AK0266
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Size:
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Introduction
The Src family of protein tyrosine kinases, which includes Src, Lyn, Fyn, Yes, Lck, Blk, and Hck, are important in the regulation of growth and differentiation of eukaryotic cells. Src activity is regulated by tyrosine phosphorylation at two sites, but with opposing effects. While phosphorylation at Tyr416 in the activation loop of the kinase domain upregulates enzyme activity, phosphorylation at Tyr527 in the carboxy-terminal tail by Csk renders the enzyme less active. Lyn is a member of the Src family that is predominantly expressed in hematopoietic cells. Lyn participates in signaling from multiple cell surface receptors such as the B cell Ag receptor (BCR) and CD40. Lck is essential for T-lymphocyte activation and differentiation. The activity of Lck is regulated by protein kinases and phosphatases. Phosphorylation of the C-terminal tyrosine 505 serves to downregulate Lck catalytic activity, while phosphorylation at tyrosine 394 leads to an increase in Lck activity.
General Information
| Reactivity | Human, Mouse, Rabbit |
|---|---|
| Application | WB, ELISA |
| Host | Rabbit |
| Clonality | Polyclonal |
| Conjugate | HRP,Non-conjugated |
| Storage instruction | Store at -20℃. Avoid freeze / thaw cycles. |
| Research topic | Src protein family; Protein tyrosine kinase; Cell growth; Cell differentiation |
Product Includes
| Product name | Quantity | Applications | Reactivity | Host |
| c-SRC Polyclonal Antibody | 20μL | WB,IHC,IF,ELISA | Human, Mouse, Rat | Rabbit |
| Phospho-c-SRC (Tyr529) Polyclonal Antibody | 20μL | WB,IHC,ELISA | Human, Mouse, Rat, Monkey | Rabbit |
| Phospho-c-SRC (Tyr419) Polyclonal Antibody | 20μL | WB,IHC,ELISA | Human, Mouse, Rat | Rabbit |
| Phospho-c-SRC (Ser75) Polyclonal Antibody | 20μL | WB,IHC,ELISA | Human, Mouse, Rat | Rabbit |
| Goat Anti-Rabbit IgG (H+L)(peroxidase/HRP conjugated) | 120μL | WB,ELISA |
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