Phospho-EGF Receptor Antibody Sampler Kit

Catalog Number : AK0223
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Introduction

The epidermal growth factor (EGF) receptor is a transmembrane tyrosine kinase that belongs to the HER/ErbB protein family. Ligand binding results in receptor dimerization, autophosphorylation, activation of downstream signaling, internalization, and lysosomal degradation. Phosphorylation of EGF receptor (EGFR) at Tyr845 in the kinase domain is implicated in stabilizing the activation loop, maintaining the active state enzyme, and providing a binding surface for substrate proteins. c-Src is involved in phosphorylation of EGFR at Tyr845. The SH2 domain of PLCγ binds at phospho-Tyr992, resulting in activation of PLCγ-mediated downstream signaling. Phosphorylation of EGFR at Tyr1045 creates a major docking site for the adaptor protein c-Cbl, leading to receptor ubiquitination and degradation following EGFR activation. The GRB2 adaptor protein binds activated EGFR at phospho-Tyr1068. A pair of phosphorylated EGFR residues (Tyr1148 and Tyr1173) provide a docking site for the Shc scaffold protein, with both sites involved in MAP kinase signaling activation. Phosphorylation of EGFR at specific serine and threonine residues attenuates EGFR kinase activity. EGFR carboxy-terminal residues Ser1046 and Ser1047 are phosphorylated by CaM kinase II; mutation of either of these serines results in upregulated EGFR tyrosine autophosphorylation.

General Information

Reactivity	Human, Mouse, Rabbit
Application	WB, ELISA
Host	Rabbit
Clonality	Polyclonal
Conjugate	HRP,Non-conjugated
Storage instruction	Store at -20℃. Avoid freeze / thaw cycles.
Research topic	EGFR Signaling Pathway

PRODUCT INCLUDES

Cat No.	Product name	Quantity	Applications	Reactivity	Host
A340503	EGFR Polyclonal Antibody	20μL	WB, IHC, IF, ELISA	Human, Mouse, Rat	Rabbit
A340212	Phospho-EGFR (Tyr1092) Polyclonal Antibody	20μL	WB, IHC, ELISA	Human, Mouse, Rat	Rabbit
A340213	Phospho-EGFR (Tyr1172) Polyclonal Antibody	20μL	WB, ELISA	Human, Mouse, Rat	Rabbit
A340214	Phospho-EGFR (Tyr1197) Polyclonal Antibody	20μL	WB, IHC, ELISA	Human, Mouse, Rat	Rabbit
A340215	Phospho-EGFR (Tyr869) Polyclonal Antibody	20μL	WB, IF, ELISA	Human, Mouse, Rat	Rabbit
A340305	Phospho-EGFR (Tyr1069) Polyclonal Antibody	20μL	WB, ELISA	Human, Mouse, Rat, Monkey	Rabbit
A340318	Phospho-EGFR (Thr678) Polyclonal Antibody	20μL	WB, IF, ELISA	Human, Mouse, Rat, Monkey	Rabbit
A1013s	Goat Anti-Rabbit IgG (H+L) (peroxidase/HRP conjugated)	120μL	WB, ELISA	Rabbit	Goat

Phospho-EGF Receptor Antibody Sampler Kit

Introduction

General Information

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Phospho-EGF Receptor Antibody Sampler Kit

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