NF-κB Family Member Antibody Sampler Kit

Catalog Number : AK0203
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Introduction

Transcription factors of the nuclear factor κB (NF-κB)/Rel family play a pivotal role in inflammatory and immune responses. There are five family members in mammals: RelA, c-Rel, RelB, NF-κB1 (p105/p50), and NF-κB2 (p100/p52). Both p105 and p100 are proteolytically processed by the proteasome to produce p50 and p52, respectively. Rel proteins bind p50 and p52 to form dimeric complexes that bind DNA and regulate transcription. In unstimulated cells, NF-κB is sequestered in the cytoplasm by IκB inhibitory proteins. NF-κB-activating agents can induce the phosphorylation of IκB proteins, targeting them for rapid degradation through the ubiquitin-proteasome pathway and releasing NF-κB to enter the nucleus where it regulates gene expression. NIK and IKKα (IKK1) regulate the phosphorylation and processing of NF-κB2 (p100) to produce p52, which translocates to the nucleus).

General Information

Reactivity	Human, Mouse
Application	WB, ELISA
Host	Rabbit
Clonality	Polyclonal
Conjugate	HRP,Non-conjugated
Storage instruction	Store at -20℃. Avoid freeze / thaw cycles.
Research topic	NF-kB Signaling Pathway; Inflammatory and immune responses; Transcriptional regulation

PRODUCT INCLUDES

Cat No.	Product name	Quantity	Applications	Reactivity	Host
A340404	NFκB-p65 Polyclonal Antibody	20μL	WB, ELISA	Human, Mouse, Rat	Rabbit
A340130	RELB Polyclonal Antibody	20μL	WB, ELISA	Human, Mouse	Rabbit
A340489	c-Rel Polyclonal Antibody	20μL	WB, IHC, ELISA	Human	Rabbit
A340607	NFκB-p105/p50 Polyclonal Antibody	20μL	WB, IHC, IF, ELISA	Human, Mouse	Rabbit
A340606	NFκB-p100 Polyclonal Antibody	20μL	WB, IHC, IF, IP, ELISA	Human, Mouse, Rat	Rabbit
A1013s	Goat Anti-Rabbit IgG (H+L) (peroxidase/HRP conjugated)	120μL	WB, ELISA	Rabbit	Goat

NF-κB Family Member Antibody Sampler Kit

Introduction

General Information

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NF-κB Family Member Antibody Sampler Kit

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