Antibody, Antibody Sampler Kit
ALK Activation Antibody Sampler Kit
- Catalog Number : AK0111
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Introduction
Anaplastic lymphoma kinase (ALK) is a tyrosine kinase receptor for pleiotrophin (PTN), a growth factor involved in embryonic brain development. In ALK-expressing cells, PTN induces phosphorylation of both ALK and the downstream effectors IRS-1, Shc, PLCγ, and PI3 kinase. ALK was originally discovered as a nucleophosmin (NPM)-ALK fusion protein produced by a translocation. Investigators have found that the NPM-ALK fusion protein is a constitutively active, oncogenic tyrosine kinase associated with anaplastic lymphoma. Research literature suggests that activation of PLCγ by NPM-ALK may be a crucial step for its mitogenic activity and involved in the pathogenesis of anaplastic lymphomas. A distinct ALK oncogenic fusion protein involving ALK and echinoderm microtubule-associated protein like 4 (EML4) has been described in the research literature from a non-small cell lung cancer (NSCLC) cell line, with corresponding fusion transcripts present in some cases of lung adenocarcinoma. The short, amino-terminal region of the microtubule-associated protein EML4 is fused to the kinase domain of ALK.
General Information
| Reactivity | Human, Mouse, Rabbit |
|---|---|
| Application | WB, ELISA |
| Host | Rabbit |
| Clonality | Polyclonal |
| Conjugate | HRP,Non-conjugated |
| Storage instruction | Store at -20℃. Avoid freeze / thaw cycles. |
| Research topic | Developmental Biology |
Product Includes
| Product name | Quantity | Applications | Reactivity | Host |
| Phospho-JAK3 (Tyr785) Polyclonal Antibody | 20μL | WB,IHC,ELISA | Human, Mouse, Rat | Rabbit |
| Phospho-JAK2 (Tyr1007) Polyclonal Antibody | 20μL | WB,IHC,ELISA | Human, Mouse, Rat | Rabbit |
| Phospho-STAT3 (Tyr705) Polyclonal Antibody | 20μL | WB,IHC,IP,ELISA | Human, Mouse, Rat | Rabbit |
| Phospho-STAT5 (Ser726/731) Polyclonal Antibody | 20μL | WB,IHC,ELISA | Human, Mouse, Rat | Rabbit |
| Phospho-ERK 1/2 (Thr202/Tyr204) Polyclonal Antibody | 20μL | WB,IHC,ELISA | Human,Mouse,Rat | Rabbit |
| Phospho-AKT1 (Ser473) Polyclonal Antibody | 20μL | WB,IHC,IF,ELISA | Human, Mouse, Rat | Rabbit |
| Phospho-c-SRC (Tyr419) Polyclonal Antibody | 20μL | WB,IHC,ELISA | Human, Mouse, Rat | Rabbit |
| Phospho-PLCG1 (Tyr783) Polyclonal Antibody | 20μL | WB,IHC,ELISA | Human, Mouse, Rat, Monkey | Rabbit |
| Goat Anti-Rabbit IgG (H+L)(peroxidase/HRP conjugated) | 120μL | WB,ELISA |
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