TRADD Polyclonal Antibody
- Catalog Number : A340688
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Introduction
Apoptosis mediated by death factors like FasL and TNF-α involves the formation of a death-inducing signaling complex (DISC) to their respective receptors (1). Upon ligand activation to their receptors, Fas and TNF-R1 associate with death domain (DD) containing adaptor proteins FADD (Fas associated death domain) (2,3) and TRADD (TNF-R1 associated death domain) (4). In addition to its carboxy-terminal DD, FADD contains an amino-terminal death effector domain (DED) that binds to DEDs found on caspase-8 which leads to activation of this initiator caspase (5,6). Caspase-8 subsequently activates downstream effector caspases, like caspase-3, resulting in the cleavage of proteins involved in the execution of apoptosis. Unlike FADD, TRADD does not contain a DED (4). Apoptosis driven by TNF-R1 binding to TRADD involves association of TRADD and FADD which then leads to activation of caspase-8 (7).
General Information
| Reactivity | Mouse, Monkey |
|---|---|
| Application | WB, IHC, ELISA |
| Clonality | Polyclonal |
| Conjugate | Non-conjugated |
| Uniprot | Q15628 |
| Isotype | IgG |
| Immunogen | Synthesized peptide derived from the C-terminal region of human TRADD |
| Storage buffer | PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.3 |
| Storage instruction | Store at -20℃. Avoid freeze / thaw cycles. |
| Alias | 9130005N23Rik,AA930854,TNFR1 associated DEATH domain protein,TNFR1-associated DEATH domain protein,TNFRSF1A associated via death domain,TNFRSF1A-associated via death domain,tradd,TRADD,Tumor necrosis factor receptor type 1 associated DEATH domain protein,Tumor necrosis factor receptor type 1-associated DEATH domain protein |
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