TCF7 Polyclonal Antibody
- Catalog Number : A340686
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Introduction
Transcriptional activator involved in T-cell lymphocyte differentiation. Necessary for the survival of CD4(+) CD8(+) immature thymocytes. Isoforms lacking the N-terminal CTNNB1 binding domain cannot fulfill this role. Binds to the T-lymphocyte-specific enhancer element (5'-WWCAAAG-3') found in the promoter of the CD3E gene. May also act as feedback transcriptional repressor of CTNNB1 and TCF7L2 target genes. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7 and CTNNB1.
General Information
| Reactivity | Mouse |
|---|---|
| Application | WB, IHC, ELISA |
| Clonality | Polyclonal |
| Conjugate | Non-conjugated |
| Uniprot | P36402 |
| Isotype | IgG |
| Immunogen | Synthesized peptide derived from the N-terminal region of human TCF-1 |
| Storage buffer | PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.3 |
| Storage instruction | Store at -20℃. Avoid freeze / thaw cycles. |
| Alias | FLJ36364,MGC47735,OTTHUMP00000159391,T cell factor 1,T cell specific transcription factor 1,T-cell factor 1,T-cell-specific transcription factor 1,TCF-1,TCF-7,TCF1,Tcf7,TCF7 transcription factor 7,TCF7,Transcription factor 7 (T cell specific HMG box),Transcription factor 7,Transcription factor-7,T-cell specific,Transcription factor-7,T-cell specific,1 |
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