PDHA1 Polyclonal Antibody
- Catalog Number : A340629
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Introduction
The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle. The PDH complex is composed of multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). The E1 enzyme is a heterotetramer of two alpha and two beta subunits. This gene encodes the E1 alpha 1 subunit containing the E1 active site, and plays a key role in the function of the PDH complex. Mutations in this gene are associated with pyruvate dehydrogenase E1-alpha deficiency and X-linked Leigh syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
General Information
| Reactivity | Rat, Mouse |
|---|---|
| Application | WB, IHC, ELISA |
| Clonality | Polyclonal |
| Conjugate | Non-conjugated |
| Uniprot | P08559 |
| Isotype | IgG |
| Immunogen | Synthesized peptide derived from the C-terminal region of human PDHA1 |
| Storage buffer | PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.3 |
| Storage instruction | Store at -20℃. Avoid freeze / thaw cycles. |
| Alias | ODPA,PDH,PDHA,PDHA1,PDHCE1A,PDHE1 A type I,PDHE1-A type I,PHE1A,Pyruvate Dehydrogenase (lipoamide) alpha 1,Pyruvate dehydrogenase complex,E1 alpha polypeptide 1,Pyruvate Dehydrogenase E1 alpha,Pyruvate dehydrogenase E1 component subunit alpha,somatic form,mitochondrial |
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