Cyclin H Polyclonal Antibody

Catalog Number : A340495
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Introduction

Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminus domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.

General Information

Reactivity	Rat, Mouse
Application	WB, IF, IHC, ELISA
Clonality	Polyclonal
Conjugate	Non-conjugated
Uniprot	P51946
Isotype	IgG
Immunogen	Synthesized peptide derived from human Cyclin H around the non-phosphorylation site of T315.
Storage buffer	PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.3
Storage instruction	Store at -20℃. Avoid freeze / thaw cycles.
Alias	6330408H09Rik,AI661354,AV102684,AW538719,CAK,CAK complex subunit,ccnh,CCNH,CDK activating kinase,CDK activating kinase complex subunit,Cyclin dependent kinase activating kinase,cyclin dependent kinase activating kinase complex subunit,Cyclin H,Cyclin-H,CyclinH,MO15 associated protein,MO15-associated protein,p34,p36,p37