Phospho-Histone H2A.X (Ser139) Polyclonal Antibody
- Catalog Number : A340376
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Introduction
Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation.
General Information
| Reactivity | Rat, Mouse |
|---|---|
| Application | WB |
| Clonality | Polyclonal |
| Conjugate | Non-conjugated |
| Uniprot | P16104 |
| Isotype | IgG |
| Immunogen | Synthesized peptide derived from human Histone H2A.X around the phosphorylation site of Ser139 |
| Storage buffer | PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.3 |
| Storage instruction | Store at -20℃. Avoid freeze / thaw cycles. |
| Alias | H2A histone family member X,H2A histone family member X,H2A.FX,H2A.X,H2a/x,H2AFX,H2AX,H2AX,Histone H2A.X |
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