Phospho-PAK1 (Thr212) Polyclonal Antibody
- Catalog Number : A340346
- Number : A340346-20ug
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Introduction
The activated kinase acts on a variety of targets. Likely to be the GTPase effector that links the Rho-related GTPases to the JNK MAP kinase pathway. Activated by CDC42 and RAC1. Involved in dissolution of stress fibers and reorganization of focal complexes. Involved in regulation of microtubule biogenesis through phosphorylation of TBCB. Activity is inhibited in cells undergoing apoptosis, potentially due to binding of CDC2L1 and CDC2L2.
General Information
| Reactivity | Human, Rat, Mouse |
|---|---|
| Application | WB, IF, ELISA, IHC-p |
| Clonality | Polyclonal |
| Conjugate | Non-conjugated |
| Uniprot | Q13153 |
| Isotype | IgG |
| Immunogen | The antiserum was produced against synthesized peptide derived from human PAK1 around the phosphorylation site of Thr212. AA range:178-227 |
| Assay principle | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. |
| Purity | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Molecular Weight | 65 KD |
| Formula | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Storage instruction | Store at -20℃. Avoid freeze / thaw cycles. |
| Alias | PAK1; Serine/threonine-protein kinase PAK 1; Alpha-PAK; p21-activated kinase 1; PAK-1; p65-PAK |
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