Phospho-AMPK alpha1/2 (Thr183/172) Polyclonal Antibody
- Catalog Number : A340323
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Introduction
AMPK (for 5'-AMP-activated protein kinase) is a heterotrimeric complex comprising a catalytic α subunit and regulatory β and γ subunits. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. AMPK is activated by high AMP and low ATP through a mechanism involving allosteric regulation, promotion of phosphorylation by an upstream protein kinase known as AMPK kinase, and inhibition of dephosphorylation.Activated AMPK can phosphorylate and regulate in vivo hydroxymethylglutaryl-CoA reductase and acetyl-CoA carboxylase, which are key regulatory enzymes of sterol synthesis and fatty acid synthesis, respectively.
General Information
Reactivity | Rat, Mouse, Monkey |
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Application | WB, IHC, ELISA |
Clonality | Polyclonal |
Conjugate | Non-conjugated |
Uniprot | Q13131,P54646 |
Isotype | IgG |
Immunogen | Synthesized peptide derived from human AMPKα1/2 around the phosphorylation site of Thr183/172 |
Storage buffer | PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.3 |
Storage instruction | Store at -20℃. Avoid freeze / thaw cycles. |
Alias | PRKAA1,AMPK1,5'-AMP-activated protein kinase catalytic subunit alpha-1,AMPK subunit alpha-1,Acetyl-CoA carboxylase kinase,ACACA kinase,Hydroxymethylglutaryl-CoA reductase kinase,HMGCR kinase,Tau-protein kinase PRKAA1,PRKAA2,AMPK, |