Phospho-IKK alpha (Thr23) Polyclonal Antibody

Catalog Number : A340240
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Introduction

Acts as part of the IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. As part of the non-canonical pathway of NF-kappa-B activation, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. Also phosphorylates NCOA3. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines.

General Information

Reactivity	Rat, Mouse
Application	WB, IHC, ELISA
Clonality	Polyclonal
Conjugate	Non-conjugated
Uniprot	O15111
Isotype	IgG
Immunogen	Synthesized peptide derived from human IKKα around the phosphorylation site of Thr23
Storage buffer	PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
Storage instruction	Store at -20℃. Avoid freeze / thaw cycles.
Alias	chuk,CHUK1,Conserved Helix Loop Helix Ubiquitous Kinase,Conserved helix loop ubiquitous kinase,Conserved helix-loop-helix ubiquitous kinase,I Kappa B Kinase 1,I Kappa B Kinase Alpha,I-kappa-B kinase 1,I-kappa-B kinase alpha,IkappaB kinase,IkB kinase alpha subunit,IkBKA,IKK 1,IKK A,IKK a kinase,IKK-A,IKK-alpha,IKK1,IKKA,IKKA,Inhibitor Of Kappa Light Polypeptide Gene Enhancer In B Cells,Inhibitor Of Nuclear Factor Kappa B Kinase Alpha Subunit,Inhibitor of nuclear factor kappa-B kinase subunit alpha,NFKBIKA,Nuclear Factor Kappa B Inhibitor Kinase Alpha,Nuclear factor NF kappa B inhibitor kinase alpha,Nuclear factor NF-kappa-B inhibitor kinase alpha,Nuclear factor NFkappaB inhibitor kinase alpha,Nuclear Factor Of Kappa Light Chain Gene Enhancer In B Cells Inhibitor,TCF-16,TCF16,Transcription factor 16