Phospho-CHEK2 (Ser516) Polyclonal Antibody
- Catalog Number : A340208
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Introduction
Regulates cell cycle checkpoints and apoptosis in response to DNA damage, particularly to DNA double-strand breaks. Inhibits CDC25C phosphatase by phosphorylation on 'Ser-216', preventing the entry into mitosis. May also play a role in meiosis. Regulates the TP53 tumor suppressor through phosphorylation at 'Thr-18' and 'Ser-20'.
General Information
Reactivity | Monkey |
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Application | WB, ELISA |
Clonality | Polyclonal |
Conjugate | Non-conjugated |
Uniprot | O96017 |
Isotype | IgG |
Immunogen | Synthesized peptide derived from human Chk2 around the phosphorylation site of Ser516 |
Storage buffer | PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4 |
Storage instruction | Store at -20℃. Avoid freeze / thaw cycles. |
Alias | CDS 1,Cds1,Cds1 homolog,Checkpoint kinase 2,Checkpoint like protein CHK2,CHEK 2,Chek2,Chk 2,CHK2 checkpoint homolog (S. pombe),CHK2 checkpoint homolog,CHK2,hCds1,HuCds 1,LFS 2,LFS2,PP1425,RAD 53,RAD53,Rad53 homolog,Serine/threonine protein kinase Chk2,Serine/threonine-protein kinase Chk2 |