Introduction
Chloroquine phosphate is a 4-aminoquinoline anti-malarial and anti-rheumatoid agent.
Chloroquine is a member of the quinolone family and is a weak intercalator. Chloroquine is used to treat amebiasis, rheumatoid arthritis, discoid and systemic lupus erythematosus.
DNA intercalator. It can also be used to improve transfection efficiency.
Chloroquine diphosphate has been used in:
· In vitro anti-plasmodium test
· Transfection and infection test
· Autophagy inhibition
· Differentiation of induced pluripotent stem cells (iPS) into cardiomyocytes
· Infected blood flow treatment
Chloroquine is a member of the quinolone family and is a weak intercalator. Chloroquine is used to treat amebiasis, rheumatoid arthritis, discoid and systemic lupus erythematosus.
DNA intercalator. It can also be used to improve transfection efficiency.
Chloroquine diphosphate has been used in:
· In vitro anti-plasmodium test
· Transfection and infection test
· Autophagy inhibition
· Differentiation of induced pluripotent stem cells (iPS) into cardiomyocytes
· Infected blood flow treatment
General Information
| Application | Chemical |
|---|---|
| Cas No. | 50-63-5 |
| Purity | ≥ 98% |
| Molecular Weight | 515.86 |
| Formula | C18H26ClN3•2H3PO4 |
| Solubility | Freely soluble in water, very slightly soluble in Alcohol and in Methanol |
| Storage instruction | Store at 0 - 8 °C |
| Alias | Chloroquine diphosphate;Arechin;Avloclor;Malaquin;Tresochin;7-Chloro-4-[4-(diethylamino)-1-methylbutylamino]quinoline Diphosphate;N4-(7-Chloro-4-quinolyl)-N1,N1-diethyl-1,4-pentanediamine Diphosphate |
|
Grade |
BP |
|---|---|
|
Melting Point |
195 - 218 °C |
|
pH |
3.5 - 4.5 |
|---|---|
|
Appearance |
White to off-white crystalline powde |
.png)