General Information
| Application | Inhibitor |
|---|
| Description | PD0332991 is a highly selective inhibitor of CDK4/6 with IC50 of 11 nM/16 nM. It shows no activity against CDK1/2/5, EGFR, FGFR, PDGFR, InsR, etc. Phase 2/3. |
|---|---|
| Cas NO. | 827022-32-2 |
| Purity | ≥98% |
|---|---|
| Molecular Weight |
483.99 |
| Formula | C24H29N7O2.HCl |
| Solubility |
DMSO : 13 mg/ml Water : <1 mg/ml Ethanol: <1 mg/ml |
|---|
| Alias | N/A |
|---|
| Target / IC50 |
Cdk4/cyclin D3 : 9 nM Cdk4/cyclin D1 : 11 nM Cdk6/cyclin D2 : 16 nM DYRK1A : 2000 nM MAPK : 8000 nM |
|---|
| Storage |
Powder : -20°C for 3 years Solvent : -80°C for 6 months |
|---|
|
|
1 mg |
5 mg |
10 mg |
|
|
1 mM |
2.0662 mL | 10.3308 mL | 20.6616 mL | |
| 5 mM | 0.4132 mL | 2.0662 mL | 4.1323 mL | |
| 10 mM | 0.2066 mL | 1.0331 mL | 2.0662 mL | |
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