General Information
| Application | Inhibitor |
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| Description | Ruboxistaurin hydrochloride is a isozyme-selective inhibitor of protein kinase C (PKC), a competitive reversible inhibitors of PKCβI and PKCβII with IC50 value of 4.7 nM and 5.9 nM respectivily. In vivo: A significant up-regulation of TGF-b1, Smad2 and Smad3 mRNA expression was observed in diabetic rats, which was alleviated by administration of ruboxistaurin. |
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| Cas NO. | 169939-93-9 |
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| Purity | ≥99% |
|---|---|
| Molecular Weight | 505.01 |
| Formula | C28H29ClN4O3 |
| Solubility |
DMSO : 6.8 mg/mL |
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| Alias | N/A |
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| Target / IC50 |
PKCβI : 4.7 nM PKCβII : 5.9 nM |
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| Storage |
Powder : -20°C for 3 years Solvent : -80°C for 6 months |
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|
|
1 mg |
5 mg |
10 mg |
|
|
1 mM |
1.9802 mL | 9.9008 mL | 19.8016 mL | |
| 5 mM | 0.3960 mL | 1.9802 mL | 3.9603 mL | |
| 10 mM | 0.1980 mL | 0.9901 mL | 1.9802 mL | |
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