General Information
| Application | Inhibitor |
|---|
| Description | BMS-777607 is a Met-related inhibitor for c-Met, Axl, Ron and Tyro3 with IC50 of 3.9 nM, 1.1 nM, 1.8 nM and 4.3 nM, 40-fold more selective for Met-related targets versus Lck, VEGFR-2, and TrkA/B, and more than 500-fold greater selectivity versus all other receptor and non receptor kinases. Phase1/2 |
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| Cas NO. | 1025720-94-8 |
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| Purity | ≥99% |
|---|---|
| Molecular Weight | 512.89 |
| Formula | C25H19ClF2N4O4 |
| Solubility |
DMSO : 47 mg/mL Ethanol : Insoluble Water : Insoluble |
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| Alias | N/A |
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| Target / IC50 |
Axl : 1.1 nM RON : 1.8 nM Met : 3.9 nM Tyro3 : 4.3 nM Mer : 14 nM |
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| Storage |
Powder : -20°C for 3 years |
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1 mg |
5 mg |
10 mg |
|
|
1 mM |
1.9497 mL | 9.7487 mL | 19.4974 mL | |
| 5 mM | 0.3899 mL | 1.9497 mL | 3.8995 mL | |
| 10 mM | 0.1950 mL | 0.9749 mL | 1.9497 mL | |
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