General Information
| Application | Inhibitor |
|---|
| Description | Cabozantinib (XL184, BMS-907351) is a potent VEGFR2 inhibitor with IC50 of 0.035 nM and also inhibits c-Met, Ret, Kit, Flt-1/3/4, Tie2, and AXL with IC50 of 1.3 nM, 4 nM, 4.6 nM, 12 nM/11.3 nM/6 nM, 14.3 nM and 7 nM, respectively. |
|---|
| Cas NO. | 849217-68-1 |
|---|
| Purity | ≥98% |
|---|---|
| Molecular Weight | 501.51 |
| Formula | C28H24FN3O5 |
| Solubility |
DMSO : 100 mg/mL Ethanol : Insoluble Water : Insoluble |
|---|
| Alias | N/A |
|---|
| Target / IC50 |
VEGFR2/KDR : 0.035 nM c-Met : 1.3 nM |
|---|
| Storage |
Powder : -20°C for 3 years |
|---|
|
|
1 mg |
5 mg |
10 mg |
|
|
1 mM |
1.9940 mL | 9.9699 mL | 19.9398 mL | |
| 5 mM | 0.3988 mL | 1.9940 mL | 3.9880 mL | |
| 10 mM | 0.1994 mL | 0.9970 mL | 1.9940 mL | |
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