General Information
| Application | Inhibitor |
|---|
| Description | AT406 (SM-406) is a potent Smac mimetic and an antagonist of IAP (inhibitor of apoptosis protein via E3 ubiquitin ligase), binding to XIAP-BIR3, cIAP1-BIR3 and cIAP2-BIR3 with Ki of 66.4 nM, 1.9 nM, and 5.1 nM, 50- to 100-fold higher affinities than the Smac AVPI peptide. Phase 1. |
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| Cas NO. | 1071992-99-7 |
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| Purity | ≥98% |
|---|---|
| Molecular Weight | 561.71 |
| Formula | C32H43N5O4 |
| Solubility |
DMSO : 100 mg/mL Ethanol : 100 mg/mL Water : Insoluble |
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| Alias | SM-406 |
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| Target / IC50 |
cIAP1-BIR3 : 1.9 nM cIAP2-BIR3 : 5.1 nM XIAP-BIR3 : 66.4 nM |
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| Storage |
Powder : -20°C for 3 years |
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1 mg |
5 mg |
10 mg |
|
|
1 mM |
1.7803 mL | 8.9014 mL | 17.8028 mL | |
| 5 mM | 0.3561 mL | 1.7803 mL | 3.5606 mL | |
| 10 mM | 0.1780 mL | 0.8901 mL | 1.7803 mL | |
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