General Information
| Application | Inhibitor |
|---|
| Description | PD0332991 is a highly selective inhibitor of CDK4/6 with IC50 of 11 nM/16 nM. It shows no activity against CDK1/2/5, EGFR, FGFR, PDGFR, InsR, etc. Phase 2/3. |
|---|
| Cas NO. | 827022-32-2 |
|---|
| Purity | ≥98% |
|---|---|
| Molecular Weight | 483.99 |
| Formula | C24H29N7O2.HCl |
| Solubility |
DMSO : 3 mg/mL Ethanol : Insoluble Water : 30 mg/mL |
|---|
| Alias | Palbociclib hydrochloride;Palbociclib HCl; PD-0332991 hydrochloride |
|---|
| Target / IC50 |
CDK4/CyclinD1 : 11 nM CDK4/CyclinD3 : 9 nM CDK6/CyclinD2 : 15 nM |
|---|
| Storage |
Powder : -20°C for 3 years |
|---|
|
|
1 mg |
5 mg |
10 mg |
|
|
1 mM |
2.0662 mL | 10.3308 mL | 20.6616 mL | |
| 5 mM | 0.4132 mL | 2.0662 mL | 4.1323 mL | |
| 10 mM | 0.2066 mL | 1.0331 mL | 2.0662 mL | |
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