General Information
| Application | Inhibitor |
|---|
| Description | Avapritinib (BLU-285) is a small molecule kinase inhibitor that potently inhibits PDGFRα D842V mutant activity in vitro (IC50 = 0.5 nM) and PDGFRα D842V autophosphorylation in the cellular setting (IC50 = 30 nM); also a potent inhibitor of the analogous KIT mutation, D816V in KIT Exon 17 (IC50 = 0.5 nM). |
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| Cas NO. |
1703793-34-3 |
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| Purity | 98% |
|---|---|
| Molecular Weight | 498.56 |
| Formula | C26H27FN10 |
| Solubility |
DMSO : 66 mg/mL Ethanol : 3 mg/mL Water : Insoluble |
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| Target / IC50 |
PDGFRα (D842V) : 0.5 nM c-Kit (D842V) : 0.5 nM |
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|
|
1 mg |
5 mg |
10 mg |
|
|
1 mM |
2.0058 mL | 10.0289 mL | 20.0578 mL | |
| 5 mM | 0.4012 mL | 2.0058 mL | 4.0116 mL | |
| 10 mM | 0.2006 mL | 1.0029 mL | 2.0058 mL | |
| Storage |
Powder : -20°C for 3 years Solvent : -80°C for 2 years |
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