General Information
| Application | Inhibitor |
|---|
| Description | SNS-032 (BMS-387032) has firstly been described as a selective inhibitor of CDK2 with IC50 of 48 nM in cell-free assays and is 10- and 20-fold selective over CDK1/CDK4. It is also found to be sensitive to CDK7/9 with IC50 of 62 nM/4 nM, with little effect on CDK6. Phase 1. |
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| Cas NO. |
345627-80-7 |
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| Purity | ≥98% |
|---|---|
| Molecular Weight | 380.53 |
| Formula | C17H24N4O2S2 |
| Solubility |
DMSO: 76 mg/mL Ethanol: Insoluble H2O: Insoluble |
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| Target / IC50 |
CDK9/CyclinT : 4 nM CDK2/CyclinA : 38 nM CDK2/CyclinE : 48 nM CDK7/CyclinH : 62 nM GDK-3α : 230 nM |
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| Storage |
Powder : -20°C for 3 years |
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|
|
1 mg |
5 mg |
10 mg |
|
|
1 mM |
2.6279 mL | 13.1396 mL | 26.2791 mL | |
| 5 mM | 0.5256 mL | 2.6279 mL | 5.2558 mL | |
| 10 mM | 0.2628 mL | 1.13140 mL | 2.6279 mL | |
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