General Information
| Application | Inhibitor |
|---|
| Description | Roscovitine (Seliciclib, CYC202) is a potent and selective CDK inhibitor for Cdc2, CDK2 and CDK5 with IC50 of 0.65 μM, 0.7 μM and 0.16 μM in cell-free assays. It shows little effect on CDK4/6. Phase 2 |
|---|
| Cas NO. |
186692-46-6 |
|---|
| Purity | ≥98% |
|---|---|
| Molecular Weight | 354.45 |
| Formula | C19H26N6O |
| Solubility |
DMSO: 71 mg/mL Ethanol: 6 mg/mL H2O: Insoluble |
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| Target / IC50 |
CDK5/p35 : 5 μM Cdc2/CyclinB : 0.65 μM CDK2/CyclinA : 0.7 μM CDK2/CyclinE : 0.7 μM ERK2 : 14 μM |
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| Storage |
Powder : -20°C for 3 years |
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|
|
1 mg |
5 mg |
10 mg |
|
|
1 mM |
2.8213 mL | 14.1064 mL | 28.2127 mL | |
| 5 mM | 0.5643 mL | 2.8213 mL | 5.6425 mL | |
| 10 mM | 0.2821 mL | 1.4106 mL | 2.8213 mL | |
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