Protein Biology, COVID-19 
, COVID-19 (SARS-CoV-2) proteins
Recombinant SARS-COV-2 Nucleocapsid Protein (His Tag)
- Catalog Number : P0077
- Number : P0077-100ug
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Introduction
Coronaviruses are enveloped viruses with a positive-sense RNA genome and with a nucleocapsid of helical symmetry.
Coronavirus nucleoproteins localize to the cytoplasm and the nucleolus, a subnuclear structure, in both virus-infected primary cells and in cells transfected with plasmids that express N protein. Coronavirus N protein is required for coronavirus RNA synthesis, and has RNA chaperone activity that may be involved in template switch. Nucleocapsid protein is a most abundant protein of coronavirus. During virion assembly, N protein binds to viral RNA and leads to formation of the helical nucleocapsid. Nucleocapsid protein is a highly immunogenic phosphoprotein also implicated in viral genome replication and in modulating cell signaling pathways. Because of the conservation of N protein sequence and its strong immunogenicity, the N protein of coronavirus is chosen as a diagnostic tool.
Coronavirus nucleoproteins localize to the cytoplasm and the nucleolus, a subnuclear structure, in both virus-infected primary cells and in cells transfected with plasmids that express N protein. Coronavirus N protein is required for coronavirus RNA synthesis, and has RNA chaperone activity that may be involved in template switch. Nucleocapsid protein is a most abundant protein of coronavirus. During virion assembly, N protein binds to viral RNA and leads to formation of the helical nucleocapsid. Nucleocapsid protein is a highly immunogenic phosphoprotein also implicated in viral genome replication and in modulating cell signaling pathways. Because of the conservation of N protein sequence and its strong immunogenicity, the N protein of coronavirus is chosen as a diagnostic tool.
General Information
| Reactivity | Virus |
|---|---|
| Host | Baculovirus-Insect Cells |
| Purity | > 90 % as determined by reducing SDS-PAGE |
| Molecular Weight | 47.08 kDa |
| Formula | LyopHilized from sterile 20mM Tris, 500mM NaCl, pH8.0, 10% glycerol. |
| Storage instruction | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Alias | SARS-COV-2 coronavirus NP Protein;SARS-COV-2 np Protein;SARS-COV-2 novel coronavirus Nucleoprotein Protein |
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