Antibody, Antibody Sampler Kit
14-3-3 Family Antibody Sampler Kit
- Catalog Number : AK0101
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Introduction
The 14-3-3 family of proteins plays a key regulatory role in signal transduction, checkpoint control, apoptotic and nutrient-sensing pathways . 14-3-3 proteins are highly conserved and ubiquitously expressed. There are at least seven isoforms, β, γ, ε, σ, ζ, τ, and η that have been identified in mammals. The initially described α and δ isoforms are confirmed to be phosphorylated forms of β and ζ, respectively. Through their amino-terminal α helical region, 14-3-3 proteins form homo- or heterodimers that interact with a wide variety of proteins: transcription factors, metabolic enzymes, cytoskeletal proteins, kinases, phosphatases, and other signaling molecules. The interaction of 14-3-3 proteins with their targets is primarily through a phospho-Ser/Thr motif. However, binding to divergent phospho-Ser/Thr motifs, as well as phosphorylation independent interactions has been observed. 14-3-3 binding masks specific sequences of the target protein, and therefore, modulates target protein localization, phosphorylation state, stability, and molecular interactions. 14-3-3 proteins may also induce target protein conformational changes that modify target protein function. Distinct temporal and spatial expression patterns of 14-3-3 isoforms have been observed in development and in acute response to extracellular signals and drugs, suggesting that 14-3-3 isoforms may perform different functions despite their sequence similarities. Several studies suggest that 14-3-3 isoforms are differentially regulated in cancer and neurological syndromes.
General Information
| Reactivity | Human, Mouse, Rabbit |
|---|---|
| Application | WB, IF, ELISA, IHC |
| Host | Rabbit |
| Clonality | Polyclonal |
| Conjugate | HRP,Non-conjugated |
| Storage instruction | Store at -20℃. Avoid freeze / thaw cycles. |
| Research topic | 14-3-3 protein family |
Product Includes
| Product name | Quantity | Applications | Reactivity | Host |
| 14-3-3 beta/alpha Polyclonal Antibody | 20μL | WB, IHC, IF, ELISA | Human, Mouse, Rat | Rabbit |
| 14-3-3 epsilon Polyclonal Antibody | 20μL | WB, IHC, IF, ELISA | Human, Mouse, Rat | Rabbit |
| 14-3-3 zeta/delta Polyclonal Antibody | 20μL | WB, IHC, IF, IP, ELISA | Human, Mouse, Rat | Rabbit |
| 14-3-3 theta Polyclonal Antibody | 20μL | WB, IHC, IF, ELISA | Human, Mouse, Rat | Rabbit |
| 14-3-3 theta Polyclonal Antibody | 20μL | WB, IHC, IF, ELISA | Human, Mouse, Rat | Rabbit |
| Goat Anti-Rabbit IgG (H+L)(peroxidase/HRP conjugated) | 120μL | WB,ELISA |
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