ABL1 Polyclonal Antibody
- Catalog Number : A340453
- Number : A340453-20ug
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Introduction
The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9;22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1.
General Information
| Reactivity | Human, Mouse, Rabbit |
|---|---|
| Application | WB, IF, IHC, ELISA |
| Host | Rabbit |
| Clonality | Polyclonal |
| Conjugate | Non-conjugated |
| Uniprot | Human P00519；Mouse P00520 |
| Isotype | IgG |
| Immunogen | The antiserum was produced against synthesized peptide derived from human ABL1. AA range:861-910 |
| Assay principle | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. |
| Purity | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Molecular Weight | 125 KD |
| Formula | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Storage instruction | -20°C/1 year |
| Alias | ABL1; ABL; JTK7; Tyrosine-protein kinase ABL1; Abelson murine leukemia viral oncogene homolog 1; Abelson tyrosine-protein kinase 1; Proto-oncogene c-Abl; p150 |
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