Phospho-Tuberin (Ser939) Polyclonal Antibody
- Catalog Number : A340347
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Introduction
In complex with TSC1, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling. Stimulates weakly the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 in vitro. Mutations in TSC2 lead to constitutive activation of RAP1A in tumors.
General Information
| Reactivity | Rat, Mouse |
|---|---|
| Application | WB, IHC, ELISA |
| Clonality | Polyclonal |
| Conjugate | Non-conjugated |
| Uniprot | P49815 |
| Isotype | IgG |
| Immunogen | Synthesized peptide derived from human Tuberin around the phosphorylation site of S939. |
| Storage buffer | PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.3 |
| Storage instruction | Store at -20℃. Avoid freeze / thaw cycles. |
| Alias | FLJ43106,LAM,OTTHUMP00000158940,OTTHUMP00000198394,OTTHUMP00000198395,PPP1R160,Protein phosphatase 1,regulatory subunit 160,TSC complex subunit 2,tsc2,TSC2,TSC4,TSC4 gene,formerly,TSC4,formerly,Tuberin,Tuberous sclerosis 2,Tuberous sclerosis 2 protein,Tuberous sclerosis 2 protein homolog |
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