Phospho-PLCG2 (Tyr753) Polyclonal Antibody
- Catalog Number : A340335
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Introduction
The protein encoded by this gene is a transmembrane signaling enzyme that catalyzes the conversion of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to 1D-myo-inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) using calcium as a cofactor. IP3 and DAG are second messenger molecules important for transmitting signals from growth factor receptors and immune system receptors across the cell membrane. Mutations in this gene have been found in autoinflammation, antibody deficiency, and immune dysregulation syndrome and familial cold autoinflammatory syndrome 3.
General Information
| Reactivity | Rat, Mouse |
|---|---|
| Application | WB, IHC, ELISA |
| Clonality | Polyclonal |
| Conjugate | Non-conjugated |
| Uniprot | P16885 |
| Isotype | IgG |
| Immunogen | Synthesized peptide derived from human PLC γ2 around the phosphorylation site of Tyr753 |
| Storage buffer | PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.3 |
| Storage instruction | Store at -20℃. Avoid freeze / thaw cycles. |
| Alias | 1 phosphatidylinositol 4 5 bisphosphate phosphodiesterase gamma 2,1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2,EC 3.1.4.11,Phosphoinositide phospholipase C,Phosphoinositide phospholipase C-gamma-2,Phospholipase C gamma 2,Phospholipase C,gamma 2 (phosphatidylinositol specific),Phospholipase C-gamma-2,Phospholipase C-IV,PLC 2,PLC gamma 2,PLC IV,PLC-gamma-2,PLC-IV,Plcg2,PLCG2 |
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