AURKB Polyclonal Antibody
- Catalog Number : A340435
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Introduction
May be directly involved in regulating the cleavage of polar spindle microtubules and is a key regulator for the onset of cytokinesis during mitosis. Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Phosphorylates 'Ser-10' and 'Ser-28' of histone H3 during mitosis. Required for kinetochore localization of BUB1 and SGOL1. Interacts with INCENP.
General Information
| Reactivity | Rat, Mouse |
|---|---|
| Application | WB, IF, IHC, ELISA |
| Clonality | Polyclonal |
| Conjugate | Non-conjugated |
| Uniprot | Q96GD4 |
| Isotype | IgG |
| Immunogen | Synthesized peptide derived from human ARK-2 around the non-phosphorylation site of Tyr12 |
| Storage buffer | PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.3 |
| Storage instruction | Store at -20℃. Avoid freeze / thaw cycles. |
| Alias | AIK2,AIM-1,AIM1,ARK-2,ARK2,AurB,AURKB,AURKB,Aurora 1,Aurora and Ipl1 like midbody associated protein 1,Aurora kinase B,Aurora related kinase 2,Aurora- and Ipl1-like midbody-associated protein 1,Aurora-B,Aurora-related kinase 2,Aurora/IPL1 related kinase 2,Aurora/IPL1-related kinase 2,IPL1,PPP1R48,Protein phosphatase 1 regulatory subunit 48,Serine/theronine kinase 12,Serine/threonine protein kinase 12,Serine/threonine-protein kinase 12,Serine/threonine-protein kinase aurora-B,STK-1,STK1,STK12,STK5 |
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