CK-17 Monoclonal Antibody
- Catalog Number : A330116
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Introduction
May play a role in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial "stem cells". May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation. Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway. Involved in tissue repair.
General Information
| Application | WB, IP |
|---|---|
| Clonality | Monoclonal,monoclonal Clone:2K5 |
| Conjugate | Non-conjugated |
| Uniprot | Q04695 |
| Isotype | IgG |
| Immunogen | Synthetic Peptide |
| Storage buffer | PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4 |
| Storage instruction | Store at -20℃. Avoid freeze / thaw cycles. |
| Alias | 39.1,CK 17,CK-17,Cytokeratin-17,K17,K1C17,Keratin 17,keratin 17 epitope S1,keratin 17 epitope S2,keratin 17 epitope S4,Keratin 17,type I,Keratin,Keratin type I cytoskeletal 17,keratin,type i cytoskeletal 17 [version 1],Keratin-17,KRT17,PC,PC2,PCHC1,type I cytoskeletal 17 |
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