General Information
Application | Inhibitor |
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Description | Avapritinib (BLU-285) is a small molecule kinase inhibitor that potently inhibits PDGFRα D842V mutant activity in vitro (IC50 = 0.5 nM) and PDGFRα D842V autophosphorylation in the cellular setting (IC50 = 30 nM); also a potent inhibitor of the analogous KIT mutation, D816V in KIT Exon 17 (IC50 = 0.5 nM). |
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Cas NO. |
1703793-34-3 |
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Purity | 98% |
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Molecular Weight | 498.56 |
Formula | C26H27FN10 |
Solubility |
DMSO : 66 mg/mL Ethanol : 3 mg/mL Water : Insoluble |
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Target / IC50 |
PDGFRα (D842V) : 0.5 nM c-Kit (D842V) : 0.5 nM |
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|
1 mg |
5 mg |
10 mg |
|
1 mM |
2.0058 mL | 10.0289 mL | 20.0578 mL | |
5 mM | 0.4012 mL | 2.0058 mL | 4.0116 mL | |
10 mM | 0.2006 mL | 1.0029 mL | 2.0058 mL |
Storage |
Powder : -20°C for 3 years Solvent : -80°C for 2 years |
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