General Information
| Application | Chemical |
|---|
| Description | 1. Flavokawain B has potent anti-inflammatory activity, can significantly inhibit production of NO and PGE2 in LPS-induced RAW 264.7 cells. 2. Flavokawain B, the hepatotoxic constituent from kava root, induces GSH-sensitive oxidative stress through modulation of IKK/NF-κB and MAPK signaling pathways. 3. Flavokawain B induces apoptosis, has the potential usefulness of FKB for prevention and treatment of hormone-refractory prostate cancer in an adjuvant setting. 4. Flavokawain B acts through ROS generation and GADD153 up-regulation to regulate the expression of Bcl-2 family members, thereby inducing mitochondrial dysfunction and apoptosis in HCT116 cells. |
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| Cas NO. |
1775-97-9 |
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| Purity | 98% |
|---|---|
| Molecular Weight | 284.3 |
| Formula | C17H16O4 |
| Appearance | Yellow Powder |
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| Solvent |
DMSO, Chloroform, Ethyl Acetate, Acetone |
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| Storage |
Powder : 2-8°C for 2 years Solvent : aliquote at -20°C |
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|
|
1 mg |
5 mg |
10 mg |
|
|
1 mM |
3.5174 mL | 17.5871 mL | 35.1741 mL | |
| 5 mM | 0.7035 mL | 3.5174 mL | 7.0348 mL | |
| 10 mM | 0.3517 mL | 1.7587 mL | 7.0348 mL | |
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