Recombinant Human Interleukin 7(IL-7) Protein
- Catalog Number : P0080
- Number : P0080-10ug
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Introduction
Human Interleukin 7 (IL-7) is a potent lymphoid cell growth factor stimulating the proliferation of lymphoid progenitors. IL7 can associate with the hepatocyte growth factor (HGF) to form a hybrid cytokine that functions as a pre-pro-B cell growth-stimulating factor. Human IL7 cDNA encodes a 177 amino acid precursor protein containing a 25 amino acid signal peptide and a 152 amino acid mature protein. Human and mouse IL7 share 65% sequence identity in the mature region and both exhibit cross-species activity. IL-7 signals via IL-7 receptor (IL7R) activating multiple pathways including JaK/STAT and PI3K/AKT, which regulate lymphocyte survival, glucose uptake, proliferation, and differentiation. IL-7 is also associated with cytoplasmic IL2-R gamma for signal transduction.
General Information
| Application | Cell |
|---|---|
| Host | Human |
| Uniprot | P13232 |
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Molecular Weight | 18.4 kDa |
| Formula | Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl, pH 7.4. |
| Sequence | Asp26-His177 |
| Tag Info | C-6His |
| Storage instruction | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Alias | Interleukin-7; IL-7; IL7 |
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