Parathyroid Hormone (PTH) (PT0210) mouse mAb
- Catalog Number : A130248
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Introduction
Specificity：This antibody detects endogenous levels of human Parathyroid Hormone (PTH). Heat-induced epitope retrieval (HIER) TRIS-EDTA of pH8.0 was highly recommended as antigen repair method in paraffin section.
Background：parathyroid hormone(PTH) Homo sapiens This gene encodes a member of the parathyroid family of proteins. The encoded preproprotein is proteolytically processed to generate a protein that binds to the parathyroid hormone/parathyroid hormone-related peptide receptor and regulates blood calcium and phosphate levels. Excess production of the encoded protein, known as hyperparathyroidism, can result in hypercalcemia and kidney stones. On the other hand, defective processing of the encoded protein may lead to hypoparathyroidism, which can result in hypocalcemia and numbness. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
Function：
Disease: Defects in PTH are a cause of familial isolated hypoparathyroidism (FIH) [MIM:146200]. FIH exist both as autosomal dominant and recessive forms of hypoparathyroidism.,function:PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion.
Similarity: Belongs to the parathyroid hormone family.
Subcellular Location：Cytoplasmic, Membranous
Background：parathyroid hormone(PTH) Homo sapiens This gene encodes a member of the parathyroid family of proteins. The encoded preproprotein is proteolytically processed to generate a protein that binds to the parathyroid hormone/parathyroid hormone-related peptide receptor and regulates blood calcium and phosphate levels. Excess production of the encoded protein, known as hyperparathyroidism, can result in hypercalcemia and kidney stones. On the other hand, defective processing of the encoded protein may lead to hypoparathyroidism, which can result in hypocalcemia and numbness. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
Function：
Disease: Defects in PTH are a cause of familial isolated hypoparathyroidism (FIH) [MIM:146200]. FIH exist both as autosomal dominant and recessive forms of hypoparathyroidism.,function:PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion.
Similarity: Belongs to the parathyroid hormone family.
Subcellular Location：Cytoplasmic, Membranous
General Information
| Reactivity | Human |
|---|---|
| Application | IHC |
| Host | Mouse |
| Clonality | Monoclonal |
| Conjugate | Non-conjugated |
| Uniprot | P01270 |
| Isotype | IgG1, Kappa |
| Immunogen | Synthesized peptide derived from human Parathyroid Hormone (PTH) |
| Assay principle | IHC-p 1:100-500 |
| Sample type | paraffin section |
| Purity | The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. |
| Storage buffer | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Storage instruction | -20°C/1 year |
| Research topic | skeletal system development, tissue homeostasis, regulation of nucleotide metabolic process, purine nucleotide metabolic process, regulation of transcription, DNA-dependent, regulation of transcription from RNA polymerase II promoter, cellular ion homeostasis, cellular calcium ion homeostasis, cellular metal ion homeostasis, induction of apoptosis, cell surface receptor linked signal transduction, G-protein coupled receptor protein signaling pathway, G-protein signaling, coupled to cyclic nucleotide second |
| Alias | PTH |
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