Introduction
L-Chicoric Acid ((-)-Chicoric acid) is a dicaffeoyltartaric acid and a potent, selective and reversible HIV-1 integrase inhibitor with an IC50 of ~100 nM. L-Chicoric Acid inhibits HIV-1 replication in tissue culture[1][2][3].
General Information
| Cas No. | 70831-56-0 |
|---|---|
| Purity | > 98% |
| Molecular Weight | 474.37 |
| Formula | C22H18O12 |
| Solubility | DMSO : 100 mg/mL |
| Storage instruction | -20°C for 1 years │ -80°C for 6 months in solvent |
SOLUBILITY
In vitro
DMSO : 100 mg/mL
|
Preparing Stock Solutions |
concentration |
Mass |
||
|
1 mg |
5 mg |
10 mg |
||
|
1 mM |
2.1081 mL |
10.5403 mL |
21.0806 mL |
|
|
5 mM |
0.4216 mL |
2.1081 mL |
4.2161 mL |
|
|
10 mM |
0.2108 mL |
1.0540 mL |
2.1081 mL |
|
In vivo
1. Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline
Solubility: ≥ 2.5 mg/mL (5.27 mM); Clear solution
2. Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)
Solubility: ≥ 2.5 mg/mL (5.27 mM); Clear solution
3. Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2.5 mg/mL (5.27 mM); Clear solution
*All of the co-solvents are provided by MCE.
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