p21 Polyclonal Antibody
- Catalog Number : A340745
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Introduction
May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex. Inhibits DNA synthesis by DNA polymerase delta by competing with POLD3 for PCNA binding (PubMed:11595739).
General Information
| Application | WB, ELISA |
|---|---|
| Clonality | Polyclonal |
| Conjugate | Non-conjugated |
| Uniprot | P38936 |
| Isotype | IgG |
| Immunogen | Recombinant Human P21 protein |
| Storage buffer | PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.3 |
| Storage instruction | Store at -20℃. Avoid freeze / thaw cycles. |
| Alias | CDKI,CDKN1A-interacting zinc finger protein 1,Cip1-interacting zinc finger protein,CIZ1,CIZ1,cyclin dependent inhibitor 1A,LSFR1,Melanoma differentiation-associated protein,NP94,Nuclear protein NP94,OPHN3,P21,Zinc finger protein 356,ZNF356 |
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