TRAF3 Polyclonal Antibody
- Catalog Number : A340690
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Introduction
Regulates pathways leading to the activation of NF-kappa-B and MAP kinases, and plays a central role in the regulation of B cell survival. Part of signaling pathways leading to the production of cytokines and interferon. Required for normal antibody isotype switching from IgM to IgG. Plays a role T-cell dependent immune responses. Plays a role in the regulation of antiviral responses. Is an essential constituent of several E3 ubiquitin-protein ligase complexes. May have E3 ubiquitin-protein ligase activity and promote 'Lys-63'-linked ubiquitination of target proteins. Inhibits activation of NF-kappa-B in response to LTBR stimulation. Inhibits TRAF2-mediated activation of NF-kappa-B. Down-regulates proteolytic processing of NFKB2, and thereby inhibits non-canonical activation of NF-kappa-B. Promotes ubiquitination and proteasomal degradation of MAP3K14.
General Information
| Reactivity | Mouse |
|---|---|
| Application | WB, ELISA |
| Clonality | Polyclonal |
| Conjugate | Non-conjugated |
| Uniprot | Q13114 |
| Isotype | IgG |
| Immunogen | Synthesized peptide derived from the Internal region of human TRAF3. |
| Storage buffer | PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.3 |
| Storage instruction | Store at -20℃. Avoid freeze / thaw cycles. |
| Alias | CAP 1,CAP-1,CAP1,CD40 associated protein 1,CD40 binding protein,CD40 bp,CD40 receptor associated factor 1,CD40 receptor-associated factor 1,CD40-binding protein,CD40BP,CRAF 1,CRAF1,IIAE5,LAP 1,LAP1,LMP1 associated protein,LMP1-associated protein 1,MIPT3,TNF receptor associated factor 3,TNF receptor-associated factor 3,TRAF 3,Traf3,TRAF3 |
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