CD61 Polyclonal Antibody
- Catalog Number : A340565
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Introduction
Integrin alpha-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
General Information
| Reactivity | Rat, Mouse |
|---|---|
| Application | WB, IHC, ELISA |
| Clonality | Polyclonal |
| Conjugate | Non-conjugated |
| Uniprot | P05106 |
| Isotype | IgG |
| Immunogen | Synthesized peptide derived from human Integrin β3 around the non-phosphorylation site of Tyr785. |
| Storage buffer | PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.3 |
| Storage instruction | Store at -20℃. Avoid freeze / thaw cycles. |
| Alias | BDPLT16,BDPLT2,CD 61,CD61,CD61 antigen,GP3A,GPIIIa,GT,HPA 1,HPA 4,Integrin beta 3 (platelet glycoprotein IIIa antigen CD61),Integrin beta chain beta 3,Integrin beta-3,ITB3,ITG B3,ITGB 3,ITGB3,NAIT,Platelet fibrinogen receptor beta subunit,Platelet fibrinogen receptor,beta subunit,Platelet glycoprotein IIIa,Platelet glycoprotein IIIa precursor,Platelet membrane glycoprotein IIIa,PTP |
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