AIM2 Polyclonal Antibody
- Catalog Number : A340419
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Introduction
Interferon-inducible protein AIM2 (Absent in melanoma 2) is a 343 amino acid protein belonging to the HIN-200 family. Induced by IFN-©, AIM2 is thought to act as a tumor suppressor by repressing NF˚B transcriptional activity. Localized to the nucleus, AIM2 contains one DAPIN domain and one HIN-200 domain. The DAPIN domain is composed mostly of å-helixes and is a protein-protein interaction domain capable of binding other DAPIN domains. The HIN-200 domain has been shown to bind directly to DNA, which, along with the binding of another protein ASC, results in the activation of Caspase-1.
General Information
| Application | WB, IF, IHC, ELISA |
|---|---|
| Clonality | Polyclonal |
| Conjugate | Non-conjugated |
| Uniprot | O14862 |
| Isotype | IgG |
| Immunogen | Synthesized peptide derived from the Internal region of human AIM2 |
| Storage buffer | PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.3 |
| Storage instruction | Store at -20℃. Avoid freeze / thaw cycles. |
| Alias | Absent in melanoma 2,AIM 2,Aim2,AIM2,Interferon-inducible protein AIM2,OTTHUMP00000035296,PYHIN4 |
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