Phospho-SH-PTP2 (Tyr580) Polyclonal Antibody
- Catalog Number : A340326
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Introduction
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. Two transcript variants encoding different isoforms have been found for this gene.
General Information
| Reactivity | Rat, Mouse |
|---|---|
| Application | WB, IHC, ELISA |
| Clonality | Polyclonal |
| Conjugate | Non-conjugated |
| Uniprot | Q06124 |
| Isotype | IgG |
| Immunogen | Synthesized peptide derived from human SH-PTP2 around the phosphorylation site of Tyr580 |
| Storage buffer | PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.3 |
| Storage instruction | Store at -20℃. Avoid freeze / thaw cycles. |
| Alias | BPTP3,CFC,JMML,METCDS,MGC14433,NS1,OTTHUMP00000166107,OTTHUMP00000166108,Protein tyrosine phosphatase 2,Protein tyrosine phosphatase 2C,Protein tyrosine phosphatase non receptor type 11,Protein-tyrosine phosphatase 1D,Protein-tyrosine phosphatase 2C,PTN11,PTP-1D,PTP-2C,PTP1D,PTP2C,PTPN11,SAP2,SH-PTP2,SH-PTP3,SH2 domain containing protein tyrosine phosphatase 2,SHP 2,SHP-2,Shp2,SHPTP2,SHPTP3,Syp,Tyrosine-protein phosphatase non-receptor type 11 |
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