Phospho-PKC (Thr497) Polyclonal Antibody
- Catalog Number : A340275
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Introduction
Members of the protein kinase C (PKC) family play a key regulatory role in a variety of cellular functions including cell growth and differentiation, gene expression, hormone secretion and membrane function. PKCs were originally identified as serine/threonine protein kinases whose activity was dependent on calcium and phospholipids. Diacylglycerols (DAG) and tumor promoting phorbol esters bind to and activate PKC. PKCs can be subdivided into many different isoforms (α, βI, βII, γ, δ, ε, ζ, η, θ, ι, λ, and ν). Patterns of expression for each PKC isoform differ among tissues and PKC family members exhibit clear differences in their cofactor dependencies. For instance,the kinase activities of PKC δ and ε are independent of Ca2+. On the other hand, most of the other PKC members possess phorbol ester-binding activities and kinase activities.
General Information
| Reactivity | Rat, Mouse |
|---|---|
| Application | WB, IF, IHC, ELISA |
| Clonality | Polyclonal |
| Conjugate | Non-conjugated |
| Uniprot | P17252,P05771,Q05655 |
| Immunogen | Synthesized peptide derived from human PKC around the phosphorylation site of Thr497 |
| Storage buffer | PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.3 |
| Storage instruction | Store at -20℃. Avoid freeze / thaw cycles. |
| Alias | PRKCA,PKCA,PRKACA,Protein kinase C alpha type,PKC-A,PKC-alpha,PRKCB,PKCB,PRKCB1,Protein kinase C beta type,PKC-B,PKC-beta,PRKCD,Protein kinase C delta type,Tyrosine-protein kinase PRKCD,nPKC-delta,PRKCE,PKCE,Protein kinase |
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